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Key Points Rheumatoid arthritis (RA) therapy has changed dramatically over the past 20 years The early use of DMARDs, the use of DMARD combinations, and the use of biologic agents in patients who fail to respond to DMARDs are all part of the modern approach to treating RA Strategies involving the use of low-dose glucocorticoids, as well as more-aggressive glucocorticoid regimens, have been effective Despite these successes, there remains a considerable unmet need in RA therapy Many new therapies and strategies are currently being investigated, raising hopes for an even better future for patients with this disease This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

doi: 10.1016/j.neulet.2017.03.045 84 ChenYYuMLiuXQuHChenQQianWet al

Obesity-associated variants within FTO form long-range functional connections with IRX3

The mass spectrometer was operated in positive electrospray ionization mode at a collision energy of 12 V, spray voltage of 4000 V, cone and probe temperature of 350C, cone gas flow rate of 20 L min 1 , probe gas flow rate of 40 L min 1 , and nebulizer gas flow of 60 L min 1